Peter Attia+

Metabolic liver health: how to assess risk, catch dysfunction early, and more (AMA 88 sneak peek)

In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive into the liver and its central role in metabolic health. He explains why the liver can serve as a "canary in the coal mine" for metabolic dysfunction and explores how insulin resistance, visceral fat, alcohol consumption, genetics, and hormones contribute to liver disease, along with how increasing muscle mass can benefit liver health. Peter provides a framework for understanding the progression of liver disease, highlighting which stages are reversible and why early detection matters. He explains why normal liver enzymes can pro

Mental health and the price of modernity | Linus Abrams, M.D.

This clip is from episode # 404 of The Drive which was released on 8/17/26. In the full episode, we cover: -Why estradiol may be one of the most important hormones in the brain for both men and women, and the range of neurotransmitter systems it helps regulate -Why distinguishing bipolar disorder from ordinary depression is so consequential, and how the menopause transition can bring a lifelong case to light for the first time -Why chronically elevated​ cortisol may be the most common thread running beneath modern mental health struggles, and why it is the hardest to treat directly -How much

MDMA and psilocybin for PTSD and depression | Linus Abrams, M.D.

This clip is from episode # 404 of The Drive which was released on 8/17/26. In the full episode, we cover: -Why estradiol may be one of the most important hormones in the brain for both men and women, and the range of neurotransmitter systems it helps regulate -Why distinguishing bipolar disorder from ordinary depression is so consequential, and how the menopause transition can bring a lifelong case to light for the first time -Why chronically elevated​ cortisol may be the most common thread running beneath modern mental health struggles, and why it is the hardest to treat directly -How much

404 ‒ Mental health beyond neurotransmitters: hormones in psychiatry, psychedelic therapies, & more

In this episode, Peter sits down with Dr. Linus Abrams, a psychiatrist with nearly 35 years of clinical experience specializing in mood disorders and psychopharmacology, to explore how our understanding of mental health is evolving beyond the traditional neurotransmitter model. After decades in practice, Linus began questioning many of the assumptions underlying modern psychiatry, leading him to investigate how hormones, metabolism, inflammation, circadian biology, and the endocrine system shape mood and cognition. Together, Peter and Linus examine why psychiatric care should aim not only to r

BPC-157: great marketing, not great science

This clip is from episode # 403 of The Drive which was released on 8/10/26. In the full episode, we cover: -The evidence behind BPC-157, one of the most heavily promoted peptides for healing and recovery, after three decades of claims, and the safety considerations that receive far less attention -The impact of CJC-1295 on growth hormone, and whether that could translate to outcomes like improved strength, recovery, or body composition -The overlooked connection between gray market peptides and the pharmaceutical pipeline -Where peptides show the most genuine near-term promise, from metaboli

403 ‒ Peptides: separating scientific promise from marketing hype

In this episode, Peter returns to the topic of peptides, offering a clear and accessible guide to a field surrounded by both genuine scientific promise and widespread misinformation. Peptides are increasingly marketed for everything from injury recovery and muscle growth to longevity and improved appearance, often with claims that extend far beyond the available evidence. Rather than promoting or dismissing peptides as a category, Peter presents a practical framework for evaluating any peptide: what it is, how it is supposed to work, and where the science is strong, weak, or simply absent. He

Fluffy LDL particles and cardiovascular risk | Jim Otvos, Ph.D.

This clip is from episode # 402 of The Drive which was released on 8/3/26. In the full episode, we cover: - Why LDL particle number can reveal cardiovascular risk that LDL cholesterol alone misses, and how the two can disagree -Why the popular idea that large, "fluffy" LDL particles are benign does not hold up, and the genetic condition that most clearly disproves it -How an NMR-derived score can detect insulin resistance and predict type 2 diabetes years before blood glucose begins to rise -Why GlycA, an NMR marker of chronic inflammation, offers a more stable signal than the hs-CRP test us

Metabolic Vulnerability Index and mortality prediction | Jim Otvos, Ph.D.

This clip is from episode # 402 of The Drive which was released on 8/3/26. In the full episode, we cover: - Why LDL particle number can reveal cardiovascular risk that LDL cholesterol alone misses, and how the two can disagree -Why the popular idea that large, "fluffy" LDL particles are benign does not hold up, and the genetic condition that most clearly disproves it -How an NMR-derived score can detect insulin resistance and predict type 2 diabetes years before blood glucose begins to rise -Why GlycA, an NMR marker of chronic inflammation, offers a more stable signal than the hs-CRP test us

402 ‒ NMR blood analysis: how mortality risk and more can be assessed from a single blood sample

In this episode, Jim Otvos, Ph.D., recounts the unlikely story of transforming a flawed cancer test into a new way of measuring lipoproteins, explains what standard cholesterol tests can miss and why LDL-P and apoB can inform treatment decisions beyond LDL cholesterol alone, and dispels the misconception that large, “fluffy” LDL particles are benign. View show notes here: https://peterattiamd.com/jimotvos/ Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ 0:00:00 - Intro 0:00:11

Women & fitness after 50: balancing zone 2 and lifting

This clip is from “Ask Me Anything” episode # 73 (Ep. # 356) of The Drive which was released on 7/14/25. In the full episode, we discuss: -Additional lifestyle factors that influence dementia risk: smoking, head trauma, alcohol, and sleep -Supplements for brain health: which ones matter and when they’re worth considering -Effective strategies for VO₂ max training: short vs. long intervals -Debunking the “fast vs. slow metabolism” myth: why energy balance and protein matter most for fat loss -More This AMA episode (Ep. # 356) is available exclusively for premium members. Become a member now

How people over 65 can reduce their fall risk

This clip is from episode # 342 of The Drive which was released on 3/31/25. In the full episode, we discuss: -Why it’s never too late to invest in your longevity -Advice for those managing chronic diseases later in life -Principles of good nutrition, and the importance of adequate protein intake -Why Peter decided to focus his work on longevity -Much more Watch or listen (Ep. # 342) to the full episode on my website or your favorite podcast player. View show notes here: https://peterattiamd.com/agingwell/ Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sig

Noise in your sleep environment | Peter Attia, M.D.

This clip is from “Ask Me Anything” episode # 87 (Ep. # 400) of The Drive which was released on 7/20/26. In the full episode, we cover: - Why indoor air quality often matters more than outdoor air for personal exposure, and the most common household sources - The evidence linking air pollution to​ cardiovascular disease in addition to respiratory disease, and who is most susceptible - How chronic background​ noise can affect stress physiology, blood pressure, and sleep, even at levels people stop consciously noticing - Why the noise threshold for cardiovascular and sleep effects is considera

Blue light and sleep | Peter Attia, M.D.

This clip is from “Ask Me Anything” episode # 87 (Ep. # 400) of The Drive which was released today (7/20/25). In the full episode, we cover: - Why indoor air quality often matters more than outdoor air for personal exposure, and the most common household sources - The evidence linking air pollution to​ cardiovascular disease in addition to respiratory disease, and who is most susceptible - How chronic background​ noise can affect stress physiology, blood pressure, and sleep, even at levels people stop consciously noticing - Why the noise threshold for cardiovascular and sleep effects is cons

Environmental pollution and longevity: air pollution, noise, light, EMFs, & more (AMA 87 sneak peek)

In this “Ask Me Anything” (AMA) episode, Peter explores the evidence behind environmental pollution and its impact on long-term health, separating well-supported risks from less substantiated claims while providing a practical framework for deciding which exposures deserve attention. View show notes here: https://peterattiamd.com/ama87/ Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ 00:11 - Defining environmental pollution and its role in longevity 04:57 - Why the topic of en

Monoclonal antibodies for dementia | Gayatri Devi, M.D.

This clip is from episode # 399 of The Drive which was released on 7/13/26. In the full episode, we cover: - Why a large share of healthy older adults have amyloid in their brains without any symptoms, and how that complicates the way Alzheimer's is diagnosed - Why the course of Alzheimer's is not always the steady, irreversible decline it was long assumed to be, and what changed Gayatri's mind after decades in the field - The emerging role of neuroinflammation in Alzheimer's, and the evidence linking viral infections and oral health to dementia risk - Why women face higher Alzheimer's risk

The problem with dementia treatment | Gayatri Devi, M.D.

This clip is from episode # 399 of The Drive which was released on 7/13/26. In the full episode, we cover: - Why a large share of healthy older adults have amyloid in their brains without any symptoms, and how that complicates the way Alzheimer's is diagnosed - Why the course of Alzheimer's is not always the steady, irreversible decline it was long assumed to be, and what changed Gayatri's mind after decades in the field - The emerging role of neuroinflammation in Alzheimer's, and the evidence linking viral infections and oral health to dementia risk - Why women face higher Alzheimer's risk

Can Alzheimer’s patients get better? | Gayatri Devi, M.D.

This clip is from episode # 399 of The Drive which was released today (7/13/26). In the full episode, we cover: - Why a large share of healthy older adults have amyloid in their brains without any symptoms, and how that complicates the way Alzheimer's is diagnosed - Why the course of Alzheimer's is not always the steady, irreversible decline it was long assumed to be, and what changed Gayatri's mind after decades in the field - The emerging role of neuroinflammation in Alzheimer's, and the evidence linking viral infections and oral health to dementia risk - Why women face higher Alzheimer's

399 - The evolution of Alzheimer's disease and dementia care | Gayatri Devi, M.D.

Gayatri Devi is a nationally recognized neurologist specializing in memory disorders, including Alzheimer’s disease and related dementias. In this episode, Gayatri explains how to think about dementia as a spectrum—including Alzheimer’s disease, vascular dementia, Lewy body dementia, and mixed presentations—while exploring the evolving biology of amyloid, tau, and neuroinflammation and why brain pathology does not always correlate with symptoms. View show notes here: https://peterattiamd.com/gayatridevi/ Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign u

Your grip strength could predict your lifespan

This clip is from “Ask Me Anything” episode # 71 (Ep. # 349) of The Drive which was rereleased on 7/6/26. In the full episode, I discuss: -Grip strength as a simple yet powerful predictor of all-cause mortality -Training intensity: the benefits and safety of using the “reps in reserve” method -Protein: recommended intake, quality sources, timing of consumption, and more -How experienced lifters should modify their training to support healthspan and performance in later life -Much more While this episode was originally released to subscribers, we've opened the full episode to everyone given

How muscle mass protects you from falls, disease, and decline

This clip is from “Ask Me Anything” episode # 71 (Ep. # 349) of The Drive which was rereleased on 7/6/26. In the full episode, I discuss: -Grip strength as a simple yet powerful predictor of all-cause mortality -Training intensity: the benefits and safety of using the “reps in reserve” method -Protein: recommended intake, quality sources, timing of consumption, and more -How experienced lifters should modify their training to support healthspan and performance in later life -Much more While this episode was originally released to subscribers, we've opened the full episode to everyone given

Building strength and muscle mass: optimize training & nutrition for longevity (AMA #71 rebroadcast)

In this “Ask Me Anything” (AMA) episode, Peter dives deep into the topic of muscle mass and strength, examining their essential roles in both lifespan and healthspan. View show notes here: https://peterattiamd.com/strengthandmuscle/ Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ 0:00:00 - Intro 0:00:11 - Peter’s humorous experience talking nutrition with a second grader 0:04:10 - Overview of topics, episode structure, and reasoning for focus on muscle mass and strength 0:06:5

How fasting can make chemotherapy more effective | Peter Attia, M.D.

How fasting can make chemotherapy more effective This clip is from “Ask Me Anything” episode # 72 (Ep. # 353) of The Drive which was released on 6/16/25. In the full episode, I discuss: -The risk of lean mass loss with fasting and how to mitigate it -A practical framework for using fasting as a strategy to improve body composition -The essential vitamins and minerals to supplement during prolonged fasting -Who should avoid fasting and why -Much more This AMA episode (Ep. # 353) is available exclusively for premium members. Become a member now to watch or listen on my website or your favori

5 core principles behind every successful diet | Peter Attia, M.D.

This clip is from “Ask Me Anything” episode # 75 (Ep. # 364) of The Drive which was released on 9/15/25. In the full episode, I cover: -Why diet debates are so polarizing and confusing—and a clear framework to cut through the noise -The real strengths and hidden pitfalls of ketogenic, carnivore, vegan, and Mediterranean diets -How to know if your diet is actually working with lab tests, body scans, and glucose monitoring -Why flexibility and adherence matter more than chasing the “perfect” diet -More This AMA episode (Ep. # 364) is available exclusively for premium members. Become a member

397 - Endometriosis and adenomyosis: diagnosis, fertility, reproductive aging, & emerging treatments

Renato Tomioka is a leading expert in reproductive medicine and gynecologic surgery whose unique skills allow him to diagnose and treat some of the most impactful yet frequently overlooked conditions affecting women’s health. In this episode, Renato explores endometriosis and adenomyosis. Follow Dr. Tomioka's work: Instagram: https://www.instagram.com/dr.renatotomioka/ ; Website: https://renatotomioka.com View show notes here: https://peterattiamd.com/renatotomioka/ Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:

396 – Breast cancer screening: understanding risk, deciding when to start, and more

In this episode, Peter explores the critical topic of breast cancer screening, examining why thousands of women continue to die from breast cancer each year despite the availability of effective screening tools. He explains the strengths and limitations of current screening strategies, reviews the recommendations from major medical organizations, and discusses why screening guidance can often seem confusing or contradictory. Peter outlines a practical framework for understanding breast cancer risk and personalizing screening decisions, including when to begin screening, how frequently to scree

395 – Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer’s disease, & more

Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain’s cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer’s disease risk, and unpacks the complex links between